Publications

Mécanismes Moléculaires Membranaires

1 Reversible & Microbubble Concentration-Dependent Permeabilization of an In Vitro Human Endothelial Barrier to Small Molecules Using Ultrasound: Implications for Neurodegenerative Diseases Therapy
Karen Ea, Margot Pinaud, Damien Fouan, Antoine Presset, Jean-Yves Tartu, Noboru Sasaki, Nicolas Taulier, Wladimir Urbach, Christiane Contino-Pépin, Stéphane Desgranges, Hélène Blasco, Philippe Corcia, Patrick Vourc’h, Jean-Michel Escoffre
2026 - Molecular Pharmaceutics

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2 Transient pores account for cell-penetrating peptide and homeoprotein translocation
Evgeniya Trofimenko, Nicolas Gervasi, Sylvie Perez, Nicolas Rodriguez, Delphine Ravault, Sophie Cribier, Hugues Berry, Laurent Venance, Sandrine Sagan
2026 - Proceedings of the National Academy of Sciences of the United States of America

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3 Molecular Flexibility and Electrostatic Interactions Drive the Nanoscale Structure of Coiled-Coil GM130 Protein Condensates
Pablo Mateos-Gil, Alejandro Feito, Daniel González Cava, Andrés R Tejedor, Víctor G Almendro-Vedia, Jeff Coleman, Hong Zheng, Michaela Simanjuntak, Jean N D Goder, James E Rothman, Jorge R Espinosa, Frederic Pincet, Iván López-Montero
2026 - PRX Life

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4 Development of acoustic systems for ultrasound attenuation measurement in polydimethylsiloxane (PDMS)
Mathis Pierre Claude Martin, Pascal Dargent, Wladimir Urbach, Nicolas Taulier, Alireza Ashofteh
2026 - Medical Engineering & Physics

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5 Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion
Gwendal Guerin, Thi Lan Anh Nguyen, John Manzi, Christophe Le Clainche, Julien Heuvingh, Julien Berro, Nicolas Rodriguez, Sophie Cribier, Feng-Ching Tsai
2026 - Langmuir

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6 DOUBLE EMULSION STRUCTURE FOR LOW FREQUENCIES ULTRASOUND-TRIGGERED DRUG DELIVERY
Nicolas Taulier, Wladimir Urbach, Chloë Thimonier
2026 - -PATENT-

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7 Double emulsion structure for low-frequency ultrasound-induced drug delivery
Nicolas Taulier, W. Urbach, C. Thimonier
2026 - -PATENT-

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8 Process windows for oxygen plasma activation of PDMS in confined microchannels
Maja Pakula Lundheim, Wiktor Pakula, Wladimir Urbach, Justine Laurent, Michele Lamuraglia, Nicolas Taulier
2026 - Journal of Micromechanics and Microengineering

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9 Roles of the zona pellucida in gamete fusion and of the perivitelline space in blocking polyspermy in mice
Yaëlle Dubois, Sophie Favier, Nathan Martin-Fornier, Adrien Freyss, Mohyeddine Omrane, David Stroebel, Eric Perez, Sandrine Barbaux, Ahmed Ziyyat, Nicolas Rodriguez, Christine Gourier
2026 - EMBO Reports

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10 Synaptic transmission: Munc13 assembles onto PI(4,5)P 2 -rich domains into trimers that cooperate to capture vesicles
Feng Li, Abhijith Radhakrishnan, Sudhan Gautam, Gabriel Diaz, Kalyan Sundaram, Jeff Coleman, Hong Zheng, Kirill Grushin, Matthieu Chavent, James E Rothman, Frederic Pincet
2026 - Proceedings of the National Academy of Sciences of the United States of America

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11 Acoustic Attenuation Measurement of Polydimethylsiloxane (PDMS) in Microfluidics
Mathis Martin, Pascal Dargent, Wladimir Urbach, Nicolas Taulier, Alireza Ashofteh
2025 -

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12 DOUBLE EMULSION STRUCTURE FOR LOW FREQUENCIES ULTRASOUND-TRIGGERED DRUG DELIVERY
Nicolas Taulier, Wladimir Urbach, Chloë Thimonier
2025 - -PATENT-

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13 Double emulsion structure for low frequencies ultrasound-triggered drug delivery
Nicolas Taulier, Wladimir Urbach, Chloë Thimonier.
2025 - -PATENT-

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14 Highly Stable Planar Asymmetric Suspended Membranes for Investigating Protein Dynamics and Membrane Fusion
Manindra Bera, Ramalingam Venkat Kalyana Sundaram, Jeff Coleman, Sikha Thoduvayil, Frederic Pincet, Sathish Ramakrishnan
2025 - Nature Protocols

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15 Modulation du transport membranaire par ultrasons. Application aux porines bactériennes OmpF - OmpC impliquées à la résistance aux antibiotiques chez Escherichia coli
Déhélia Chettouf, Luc Hennion, Bruno Dassy, Wladimir Urbach, Nicolas Taulier, Houssain Benabdelhak
2025 - -POSTER-

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16 Modulation du Transport Membranaire par Ultrasons : Application aux Système de Pompe d'Efflux AcrAB-TolC impliqué dans la Résistance aux Antibiotiques chez Escherichia coli
Houssain Benabdelhak, Luc Hennion, Déhélia Chettouf, Bruno Dassy, Wladimir Urbach, Nicolas Taulier
2025 -

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17 Lithium fine tunes lipid membranes through phospholipid binding
Louis Bunel, Vladimir Adrien, Jeff Coleman, Paul Heo, Frédéric Pincet
2025 - Scientific Reports

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18 Type IV Collagen surface functionalization for in vitro cell culture models
Manon Miran, Nicolas Rodriguez, Sophie Cribier, Souhir Boujday, Frederic Pincet, Kieu Ngo, Guillaume Perry
2025 - -POSTER-

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19 Intracerebral drug delivery using microbubble/nanodroplet-assisted ultrasound to address neurodegenerative diseases
Karen Ea, Nicolas Taulier, Christiane Contino-Pépin, Wladimir Urbach, Stéphane Desgranges, Hélène Blasco, Yara Al Ojaimi, Philippe Corcia, Patrick Vourc’h, Jean-Michel Escoffre
2025 - Journal of Clinical and Translational Research

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20 Biomimetic membrane in a microfluidic chip for the electrical and optical monitoring of biological reactions
Delphine Mion, Louis Bunel, Sathish Ramakrishnan, Paul Heo, Frédéric Pincet
2025 - Nature Protocols

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21 Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
Manindra Bera, Kirill Grushin, R. Venkat Kalyana Sundaram, Jasmine Hinzen, Joyce Chen, Atrouli Chatterjee, Abhijith Radhakrishnan, Seong Lee, Murugesh Padmanarayana, Jeff Coleman, Frédéric Pincet, James Rothman, Jeremy Dittman
2025 - Nature Communications

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22 Quantitative single-molecule analysis of assembly and Ca2+-dependent disassembly of synaptotagmin oligomers on lipid bilayers
Feng Li, Jeff Coleman, Lorena Redondo-Morata, R. Venkat Kalyana Sundaram, Ekaterina Stroeva, James Rothman, Frédéric Pincet
2024 - Communications Biology

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23 Double emulsion structure for low frequencies ultrasound-triggered drug delivery
Nicolas Taulier, Wladimir Urbach, Chloë Thimonier.
2024 - -PATENT-

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24 Photosensitive Nanoprobes for Rapid Isolation and Size-Specific Enrichment of Synthetic and Extracellular Vesicle Subpopulations
Jonathan Weerakkody, Tiffany Tseng, Mackenzie Topper, Sikha Thoduvayil, Abhijith Radhakrishnan, Frédéric Pincet, Themis Kyriakides, Roshan Gunasekara, Sathish Ramakrishnan
2024 - Advanced Functional Materials

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25 Dual-Ring SNAREpin Machinery Tuning for Fast Synaptic Vesicle Fusion
Matthieu Caruel, Frédéric Pincet
2024 - Biomolecules

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26 Kinetic study of membrane protein interactions: from three to two dimensions
Vladimir Adrien, Nicolas Taulier, Alice Verchère, Laura Monlezun, Martin Picard, Arnaud Ducruix, Isabelle Broutin, Frédéric Pincet, Wladimir Urbach
2024 - Scientific Reports

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27 A model for collagen secretion by intercompartmental continuities
Louis Bunel, Lancelot Pincet, Vivek Malhotra, Ishier Raote, Frédéric Pincet
2023 - Proceedings of the National Academy of Sciences of the United States of America

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28 Membrane Tubulation with a Biomembrane Force Probe
Lancelot Pincet, Frédéric Pincet
2023 - Membranes

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29 Apolipoproteins L1 and L3 control mitochondrial membrane dynamics
Laurence Lecordier, Paul Heo, Jonas H Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d’Elzius, Frederic Pincet, David Pérez-Morga, Etienne Pays
2023 - Cell Reports

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30 Acoustic droplet vaporization of perfluorohexane emulsions is induced by heterogeneous nucleation at an ultrasonic frequency of 1.1 MHz
R. Ramesh, C. Thimonier, S. Desgranges, Vincent Faugeras, F. Coulouvrat, J. Laurent, G. Marrelec, C. Contino-Pépin, W. Urbach, C. Tribet, Nicolas Taulier
2023 - Langmuir

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31 Synaptophysin Chaperones the Assembly of 12 SNAREpins under each Ready-Release Vesicle
Manindra Bera, Abhijith Radhakrishnan, Jeff Coleman, R. Venkat K. Sundaram, Sathish Ramakrishnan, Frederic Pincet, James Rothman
2023 - Proceedings of the National Academy of Sciences of the United States of America

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32 Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles
Feng Li, Kirill Grushin, Jeff Coleman, Frederic Pincet, James Rothman
2023 - Proceedings of the National Academy of Sciences of the United States of America

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33 Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer
Aniruddha Panda, Fabian Giska, Anna Duncan, Alexander Welch, Caroline Brown, Rachel Mcallister, Parameswaran Hariharan, Jean Goder, Jeff Coleman, Sathish Ramakrishnan, Frédéric Pincet, Lan Guan, Shyam Krishnakumar, James Rothman, Kallol Gupta
2023 - Nature Methods

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34 The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER
Paul Heo, Jacob A Culver, Jennifer Miao, Frederic Pincet, Malaiyalam Mariappan
2023 - Cell Reports

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35 Turbocharging synaptic transmission
James Rothman, Kirill Grushin, Manindra Bera, Frederic Pincet
2023 - FEBS Letters

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36 The beginning and the end of SNARE‐induced membrane fusion
Delphine Mion, Louis Bunel, Paul Heo, Frédéric Pincet
2022 - FEBS Open Bio

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37 Actuating tension-loaded DNA clamps drives membrane tubulation
Longfei Liu, Qiancheng Xiong, Chun Xie, Frederic Pincet, Chenxiang Lin
2022 - Science Advances

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38 Sonosensitive emulsions for therapeutic applications
Chloë Thimonier
2022 - -THESE-

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39 How to best estimate the viscosity of lipid bilayers
Vladimir Adrien, Gamal Rayan, Ksenia Astafyeva, Isabelle Broutin, Martin Picard, Patrick Fuchs, Wladimir Urbach, Nicolas Taulier
2022 - Biophysical Chemistry

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40 Vesicle capture by membrane-bound Munc13-1 requires selfassembly into discrete clusters
Feng Li, Venkat Kalyana Sundaram, Alberto T Gatta, Jeff Coleman, Sathish Ramakrishnan, Shyam S Krishnakumar, Frederic Pincet, James E Rothman
2021 - FEBS Letters

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41 In vitro evaluation of polymeric nanoparticles with a fluorine core for drug delivery triggered by focused ultrasound
L. Somaglino, L. Mousnier, A. Giron, W. Urbach, N. Tsapis, Nicolas Taulier
2021 - Colloids and Surfaces B: Biointerfaces

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42 Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly
Ramalingam Venkat Kalyana Sundaram, Huaizhou Jin, Feng Li, Tong Shu, Jeff Coleman, Jie Yang, Frederic Pincet, Yongli Zhang, James E Rothman, Shyam S Krishnakumar
2021 - FEBS Letters

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43 Nascent fusion pore opening monitored at single-SNAREpin resolution
Paul Heo, Jeff Coleman, Jean-Baptiste Fleury, James Rothman, Frederic Pincet
2021 - Proceedings of the National Academy of Sciences of the United States of America

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44 Cooperation of conical and polyunsaturated lipids to regulate initiation and processing of membrane fusion
Claire François-Martin, Amélie Bâcle, James E Rothman, Patrick Fuchs, Frederic Pincet
2021 - Frontiers in Molecular Biosciences

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45 Molecular Study of Ultrasound-Triggered Release of Fluorescein from Liposomes
Fatima El Hajj, Patrick F. J. Fuchs, Wladimir Urbach, Mohammad Nassereddine, Salah Hamieh, Nicolas Taulier
2021 - Langmuir

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46 Freezing and piercing of in vitro asymmetric plasma membrane by α-synuclein
Paul Heo, Frédéric Pincet
2020 - Communications Biology

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47 CX3CL1 homo-oligomerization drives cell-to-cell adherence
Mariano A. Ostuni, Patricia Hermand, Emeline Saindoy, Noëlline Guillou, Julie Guellec, Audrey Coens, Claude Hattab, Elodie Desuzinges-Mandon, Anass Jawhari, Soria Iatmanen-Harbi, Olivier Lequin, Patrick Fuchs, Jean-Jacques Lacapère, Christophe Combadière, Frédéric Pincet, Philippe Deterre
2020 - Scientific Reports

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48 Synaptotagmin-1 membrane binding is driven by the C2B domain and assisted cooperatively by the C2A domain
Clémence Gruget, Oscar Bello, Jeff Coleman, Shyam S Krishnakumar, Eric Perez, James E Rothman, Frederic Pincet, Stephen H Donaldson
2020 - Scientific Reports

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49 TANGO1 membrane helices create a lipid diffusion barrier at curved membranes
Ishier Raote, Andreas M Ernst, Felix Campelo, James E Rothman, Frédéric Pincet, Vivek Malhotra
2020 - eLife

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50 Liquid–liquid phase separation of the Golgi matrix protein GM130
Aleksander A Rebane, Pascal Ziltener, Lauren C Lamonica, Antonia H Bauer, Hong Zheng, Iván López‐montero, Frederic Pincet, James E Rothman, Andreas M Ernst
2020 - FEBS Letters

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